CytoSolve® reveals the synergistic effects of multicombination therapies derived from naturally-occurring compounds. Full analysis: https://vashiva.com/dr-shiva-live-quantifying-synergistic-effects-of-multi-combination-nutraceuticals-and-supplements/. Transcript Below.
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ROUGH TRANSCRIPT (Auto-Generated)
Hello, everyone. Good evening, good afternoon to wherever people are, we’re going to be doing a really interesting talk today. The title of today’s talk is quantifying synergistic effects of multi combination nutraceuticals and dietary supplements.
I also have a guest here with us, Dr. provoca is one of my colleagues who he and I did this research together. So let me share with you what we’re talking about here.
So here’s the interesting thing in the world of dietary supplements, supplements, many of you probably take supplements, what’s happened in this world of supplements is that people take a bunch of stuff, or you read a bottle, and it has a bunch of ingredients. And the issue is, do you need all of those ingredients? And all those ingredients working together in a positive way? Or a negative way? Do they fight against each other? And if they’re working together in a positive way? Is it one plus one is two? Or is it one plus one is 10? Which means the combinations of ingredients have a very powerful synergistic effect, how do you actually figure out the synergy so today’s talk is going to be about our discovery of a major paper that was just published in a very high impact journal, we’re using cytosol. We’ve actually quantified the synergistic effects of the nutraceuticals and dietary supplements.
So for those of you who are science minded, and you want to sort of chill out and listen to this, I think you’re gonna enjoy it. And then we also have Dr. provoca, the intercare.
He’s my colleague over at cytosol. So what we’re going to share today is cytosol has been was developed in 2003 2003 2007. And we’ve been using it for many, many different applications.
So today, we’re going to jump in and let me Brubaker Do you want to say anything, Dr. Vinokur. Thank you for having me on your live show that she has is that maybe second time itself is fun to be here, I’m glad you’re glad you’re sharing our recent research that we accomplished a couple of days of actually getting really good reception.
So provoker, I think what we can do is we have already shared cytosol. So we can cut a lot of the cytosol stuff, we go right to the research. Yeah, so let’s just go right into this.
And let me put this over here. Because if people on Instagram need to be able to see this, I gotta make a little bit smaller for that. So I think everyone can see this, right.
By the way, anyone who wants to know the background of cytosol. And the other things we do at bhp can go to VA shiva.com.
So this is what we’re going to cover today. First, we’re going to cover the methodology. It’s a breakthrough methodology.
And the implication this means for anyone listening is we now have a way to figure out which supplements work and which don’t provoca, you and I’ve talked about this concept of Big Pharma and big vitamin, the big vitamin guys are pushing out stuff out there without really frankly, a lot of science, they just throw stuff together. And then if it doesn’t sell, then they hire some brands. They hire either somebody to sell it for them.
But it’s really not based on science. But this is going to really sigh to solve itself as a disruptive but this new methodology is really going to disrupt a whole big vitamin world. And so we’re going to, we’ve already learned what cytosol is, we’ll talk a little bit about the cytosol open science project, then we’re going to go into what is joint pain, we’ll share with you the discoveries that we’ve done on really giving an overall architecture of joint pain, then we’re going to talk to you about the combination we discovered and then using this new approach, how we can actually identify the synergistic effects of these compounds.
So let’s just jump into it. So this is a paper you can see the papers titled in silico modeling and quantification of synergistic effects of multi combination compounds case study the attenuation of joint pain using a combination of phytonutrients. So simply put, we’re talking about here’s we’re going to be looking at this paper, and the paper really speaks to the fact that we have a methodology to apply to a combination that we actually came up with for joint pain.
So we’re sort of eating our own dog foods, we’re gonna go right into this, we you’ve already learned about cytosol, as I’ve walked you through there, but cytosol was really developed out of the mission to really revolutionize health, be it therapeutics, nutraceuticals and functional foods. And we’ve walked through that. And this is a current way that big pharma works in the pharmaceutical world of therapeutics ever compound takes them about 13 years to figure out a compound, very time consuming.
That’s why pharmaceutical companies have been losing money. And this is why they needed vaccines to save themselves. But 20% Entering clinical trials are the only thing that make it but you see before clinical trials, there’s this in vitro and in vivo phase, where they’re killing animals are testing and test tubes to even figure out if they should go test in humans.
And the reality is that this entire process is busted. And it’s like trying to build an airplane by just throwing a pilot in the pilot seat. And if he dies, you say, Oh, Jesus, he died.
And if he succeeds, then you try to explain it. And as a video said, it explains that whole essence of it in terms of we walked through it cytosol was so cytosol is fundamentally a technology that allows us to really understand using the computer without killing animals, what’s going on at the synergistic level, I wanted to let you know that we use the technology here, we’ve helped many, many companies over the last 16 years, a lot of smart, innovative companies, but we decided with all the mathematical models we’ve created, why don’t we try to use this to compute the best product we could think of from the science out there for reducing pain and inflammation, pain and discomfort and that resulted in us Creating m v 25. Using cytosol we’re gonna have more products that are going to be coming.
Let me just show you what MB 25 is about for those of you who haven’t heard about it, but this is using cytosol in a beneficial way. Not to just do research but fine combination therapies, I am barber and my hands would cramp up so that I couldn’t hold cards or knit or crochet. And they would go like that.
Not have to use this when I played cards with my grandkids and I started taking that MV 25 After betta was able to hold cards in my hand, very, very little cramping hardly at all anymore. MV 25 Hi, my name is Sandy. I’m a Taekwondo instructor, I tore my ACL during Taekwondo, I had a lot of pain and limited mobility.
I’ve been taking the MV 25 for about six months now, after the first week, I noticed the big difference after the second week, almost literally no pain. My name is Jeremy and I suffer from a lower back problem I hurt my back at work years ago. And I can go to the chiropractor and do all kinds of different things.
And nothing seems to help. And I decided to try MV 25, I didn’t notice a difference immediately. But within a few days, the pain went away and it stayed away, I’ve continued to take it.
And even when I do things that I shouldn’t do seems to go away a lot quicker than I ever did before. It’s clean food certified, it’s made in the US, if you go to big shiva.com Right on the shop, you’ll click there.
Or you can go right to MB 25 dot life either way, and then from there, you can click on the bottle and you can order if you buy six bottles, you get six bottles for free, please take advantage of it because first of all, it’s going to help you it’s going to help our movement and it really supports the fact that we want to take science based approaches to natural products cytosol itself, we have done something quite interesting where in VA Shiva itself has decided that we’re going to share cytosol with the rest of the world. So cytosol we’ve made it into what we call an Open Science Institute. And you can go find about it on va shiva.
com, you’ll see scientists of open science institute so you all the information that Dr. provoca and I sharing here is really a way to educate all of you and the Open Science Institute. But this is part of the pain and inflammation research project that we’re doing in this project that we not only have understood the molecular underpinnings of what constitutes joint health, but how those molecular mechanics go artists undergo dysfunction and create disease like osteoarthritis.
In addition to that we have model those molecular mechanisms and tested or discovered new combinations that can help with the indications like joint pain and inflammation, the blue line actually tracks the progress of each of those projects. So, the first stage is understanding the molecular architectures or seeing what we call a systems architecture for that particular indication. So, the next one is publication.
So that is we just completed that actually, this is our second publication in that area, we have also done the in silico modeling and then the screening of compounds. So that means we have looked at all available natural ingredients. And then we have understood whether those ingredients are actually having any beneficial effect on improving the joint health.
And out of that effort, actually, we were able to discover it two molecule composition formulation that we applied for IP protection in terms of getting a pet and then the same combination, we have licensed it to our subsidiaries, and that is currently on the market and getting the licensing revenue actually cytosol. He’s getting the licensing revenue from licensee here, Dr. Shiva.
Yeah. So MV 25 is a product that emerged out of this, and I think provoca today, we’re only going to talk about joint health, but we have many, many other developments and and we’re looking at work in men’s health, brain health, etc. And there we go.
And there’s many, many different projects were working on. And all of this is part of the cytosol of Open Science Institute. So let’s first of all talk about the system’s architecture of pain and inflammation.
What do we mean by this? What we mean by this is, how does pain like basically at the molecular level, what happens when you get pain and inflammation, right? So you accidentally hit your hand with a hammer where you accidentally, God forbid, cut yourself with a knife, right? You get now pain and inflammation in your body or you’re a runner, and you’ve been running on too much pavement? It’s all different aspects of it. So what happens? Well, what we’ve done is we’ve looked at all the papers out there organism extracted out the molecular mechanism and what we provide, are we going to walk right through this? Yes, so we work with the University Health Network in the Arthritis Foundation, we mapped out all the tissues that are in the knee, let’s say of knee pain, and all for every tissue, we have mapped out all the different particular types of cells that are in there. So if you look at the knee, and by the way, this can be anything shoulder, knee, anything.
You have the joint capsule, you have the articular cartilage right here, you have the meniscus, everyone knows what that is, that is a fluid filled thing that really protects any like the shock absorber you have the patella, you have the synovial membrane, you know, the fat pad and the subchondral bone, all of these components, as shown here form the knee and what we’ve done here is for the entire in this case, this joint we’ve actually if you want I can bring up the monitoring structures online version of it. Yeah, why don’t Do you bring that up? Can you share? John he should be able to share right John? Yes, sir, you should be able to so you can present Brubaker. So as I just mentioned, this is a project that we did in collaboration with the University Health Network from Toronto, Canada, what we have been able to do here is identify the molecular mechanisms that are affecting the disease that affects the joints for osteoarthritis.
So if I go in here, what you see here is the different aspects of the knee in terms of what what tissues are involved in the knee that into the subchondral, bone synovial tissue cartilage themselves. So in this project, we identified all these tissue types and click on any of these, it’ll bring up the different cells that are a part of the that particular tissue. So for example, for sandwich tissue, we have four different types of cells.
Similarly, if you will look at cartilage, and it has a one type of cell called condo sites that forms the cartilage. And if you drill a little bit deeper into it, what we see is that whenever the cell is getting affected it there are these chemical entities called ligands, that land on the surface of the cell, and then they start a cascade of chemical reactions which form or contribute towards a function of a particular organ. So the types of ligands include growth factors, cytokines and molecules.
So if you look at the cytokines, we get a list of different cytokines that initiate several different physiological functions within the corneocytes. So one of the main cytokines that is implicated in osteoarthritis is called Il one beta or interleukin one beta, that molecule actually affects so many other algebra, so many of these molecules within the sights, and those molecules actually determine the fate of what is going to happen here calculate so the molecules in green are the ones that I have and upregulates that Miss makes more of, and the ones in red are the ones that don’t I haven’t beta prevents from being expressed in the cell. So if you look at one of the key molecules called MMP 13, so this is a protein, this is a molecule that degrades the cartilage.
So if you have more of that, then you are getting your cartilage degraded because of the presence of Il one beta. So this visual representation actually allows us to see what are all those mechanisms, what kind of effects MMP 13 is having in a graphical form here, so I haven’t beta lands on the cell, this is the inside of the cartilage and then initiates several, almost 100 10s of dozens of chemical reactions that lead to what we call a catabolic effect, that is integration of the cartilage and production of m&p 13. And one of the useful thing about this visualization of this architecture is that all these lines are actually links that are active, and in the be very transparent.
So these, these links will open the paper from which we got that information. So let me sort of reiterate what Dr. Walker’s saying here is that you can think about osteoarthritis as a big orchestra of many, many chemical reactions in your body.
And in order to when you get joint pain, one of those chemical reactions is not going correctly as normal mode, so you get osteoarthritis. And how did we figure all this out? Well, there’s, in fact, there was 20,000 papers written out there. And among those 5000, were found to be, you know, decent paper relative to humans.
So from those 5000 papers, we extracted all of the chemical reactions, mapped it out and built, what we call an architecture is like reverse engineering, understanding what’s going on what Dr. provoca just shared here. So the bottom line is that every line that Dr.
provoca shared here is coming from research. So actually peer reviewed research. So we have act cytosol, aggregates all of that and then mathematically models it.
So provoker go back to that one with I think ginseng were ginseng has some effect. Yeah. And so we have mapped out all these papers.
So this is what we call a systems approach. So all of you who know our movement, truth, freedom and health know that we don’t cherry pick stuff, we take a whole system’s approach. And we’re doing that same thing with cytosol.
Thank you Brubaker. So anyway, so we’ve mapped out all the literal aspects as we know today, obviously, this is changing as it changes, so will our understanding and then at the molecular systems level, what Dr. provoca shared you there is we’ve mapped out the particular pathways that are involved in pain inflammation, one of them is called Cox two synthesis.
If you go look on the back of an Advil ibuprofen bottle, it’ll say Ibuprofen is a Cox two COX inhibitor, and what we’re looking at is a pathway where you have the IL one beta here, which lands on the cell surface and through a series of cascading pathways, it leads to the production of Cox two, okay, so il one beta that cytokine lands on the receptor, the IL one receptor and that leads to two A’s p 38. threeways, j and k two are j and k one which gives you me K er k and then finally, you have the expression of Cox two Okay, actually j and k one suppresses it Brubaker the to suppress it and J, one j and k one suppresses it, right, j and k two, I’m sorry, this is, again, it’s a part of a feedback loop. So under normal conditions, in il one beta levels are the element then you have this reaction going on, because you don’t want that overexpression of cause to surprise a back loop inhibitory feedback loop.
And this is a very important thing. Those of you to take our course we’ll understand that these feedback loops occur everywhere in nature, you can see that this is an intelligent system so it produces Cox two but nature as a way to also suppress it so you don’t want too much or that if you have a cytokine storm, you’re gonna get massive pain here without if you didn’t have the suppression. So anyway, the takeaway is CO x two that is a chemical that will increase when you have pain and inflammation.
So write that one down number one, okay, the next chemical is we’re gonna look at PG E two, which is part of this pathway called the Erica Donek acid metabolic pathway, the main thing you want to denote as PG two again, you can see it the cell membrane through a series of chemical reactions to the aircon, Donek acid, you need Arcad onic acid, this leads to the expression of PG two, which is not a good thing to have. This creates all sorts of inflammation in your body by way of example, the non steroidal anti inflammatory things like ibuprofen actually blocked this pathway right here. That’s exactly how ibuprofen work PG two, if you were to look in your blood would be highly expressed when you have pain variable number two that you need to lower if you want to reduce pain.
Next is TRP v one you want to explain this one Brubaker. So TRPV. One is a receptor that is found on several of these cells, including the nerve cells.
And when you have an expression of PG two, it lands on the cells at the cell surface and initiates a cascade of reaction that leads to activation of edema, you have more of these receptor on the surface. So basically, again, your body has all these chemical reactions, but pain, actual physical pain at the nerve is when you have high levels of pain, you have TRP V one, the PG two is really inflammation, and so is Cox two, but this is really, really associated with pain. So that’s variable number three.
Next is CG RP. So TRPV one, then we’ll land on another receptor. So that one is actually a calcium channel.
And when you have the overexpression of TRPV, one or more of those channels on the cell surfaces where once they get activated, you have calcium coming in from outside to inside that initiates the C’s offense sleep to the production of his neuropeptide called CGRP, which is what conveys pain the brain, I think the important thing to see is here is the cell surface, here’s the cytoplasm, here’s a nucleus. So you can actually see that these different chemicals are actually making your DNA because it’s in the nucleus create these proteins. So you have CGRP, that’s where you get the actual pain.
So that’s a fourth biomarker, the fourth variable. And then finally, we have our iOS lot of some of you may be interested in taking antioxidants. Oxidative stress is when your body quote unquote, is undergoing rusting.
So here’s the pathway, every chemical reaction basically produces reactive oxygen species, which are various types of things. One of them is h2o Two, for example. And these reactive oxygen species are what are involved in oxidative stress pathways, the result of them, so you want to also knock these out.
So you have again, let’s review them you have Cox two PG two TRP, V one CGRP. And reactive oxygen species. I mean, there’s various ones, but we’re calling them RLS.
So the goal here is from a very fundamental standpoint, is you have and there could be others, there’s five chemicals that are produced your body produces when you have pain and inflammation and discomfort and swelling going on. And what we want to do is to lower them, so they’re high, and you want to lower that. So if you’re looking at any one of these supplements, you start to take you have to ask yourself now that you have a little bit of education on this, you can say, Hey, is that supplement lowering? RLS? Is it lowering CGRP? Is it lowering TRPV? One is it lowering PG two, we just told you that ibuprofen really affects us ibuprofen really doesn’t go effect these but it has a lot of effect on just this.
So if you wanted to create like the really good supplement, you want to hit all of those five biomarkers. And so when we discovered MV 25, that was our goal, we wanted to find stuff in nature that would essentially have a powerful effect on all those five mechanisms. So that’s what we’re talking about here.
So what is mv 25 MV 25 We never thought we’d be in the supplements, business provoca we thought we were all going to just help others do better supplements, we realize these guys move very, very slow. And many of them didn’t even care about science. And there are there are people who do we help them Okay, so any one of you listening out there who has his own supplement, and you’re serious about it, some people are selling stuff, and they’re selling a lot of it, but they’re afraid ever to run it through cytosol because they’re afraid we may find out it really doesn’t work.
But anyway, MD 25 To get back is we found a combination of two ingredients that come from parsley and from bitter orange. And we have a patent on this. And we found a very powerful way to combine these to hit these all those four pathways which affect all those five biomark.
And the goal is and by the way, a lot of people you notice a lot of people rocker we’ve seen will say Oh, that’s good, that’s bad. Don’t eat this. Don’t eat that.
Well, in science, it’s all about how much it’s not like that’s good or bad and the ratio so that’s the alchemy, the traditional people in medicine, like the traditional medicine healers 1000s of years ago in India knew this. They knew the particular combinations. So beware Have people who suddenly say, Oh, don’t eat that don’t eat this, it really comes down to dosage, how much you can really have a lot of a good thing and hurt yourself, you know.
And sometimes you need only small amounts of things to have an effect, there’s been quite a bit of work done on Mercury, a very, very small doses, Mercury is actually has an positive effect on neurological issues. A low amounts of arsenic has a positive effects on cardiovascular issues. And people have known this for years.
But if you eat too much, you can affect things. So it’s all about dose. So what we are trying to do here is figure out the right dosage of these two combinations that will block that’s what this hammer symbol here means block these variables and lower costs to lower p g to lower, these two variables of payment are less.
So you’re talking about five different variables and think about the billions of combinations of these two ingredients. You could have trillions, how do you find the right combination? That’s where cytosol comes in. So using cytosol, we mathematically modeled all these and we quantified the synergistic effects.
So first of all, I think it’s important for Bakker everyone to understand the concept of synergy the concept of additive and the concept of antagonistic did it in a previous video briefly, but we promised in that video, we go deep into this paper. So the best way to think about antagonistic is you take supplement a or compound and compound B and you put them together and they actually annihilate each other. They don’t really do what you want it to do.
This happens we discovered in bodybuilding people are taking they drink a lot of caffeine and then you take arginine. Well, arginine will increase nitric oxide caffeine actually lowers it. So before a workout, they’ll say, Oh, I’m going to take some bargaining because I want the blood flow.
And then they’ll drink a ton of coffee, which actually will give you a stimulant to work hard, but it’s lowering the nitric oxide. So that’s an example of an antagonistic effect. Do you have any other examples provocative and antagonistic effect? Medications like the blood thinners, they they have adverse effects with the other ones? Because when you have bad thinners, and there’s a chance that fluids can leak out of blood vessels, and then it can actually cause damage? Then they advise against combining blood thinners with certain medications are alkaloids and other one.
Yeah, yeah, it is more than likely it is going to cause adverse effects with any of the heart medications or the stabilizers and so on the antagonistic compounds. Yeah. So by the way, the average 80 year old is now on 12 different medication 12 in the United States.
And so people are taking all these medications and the drug interaction, people don’t even understand what what cytosol we can really get a handle on this far better than the black art that’s done today. So that’s an important point. So now to that’s this antagonistic effect, the fact is, you take compound a, let’s say, we take some level of some variable, and it’s let’s say, I took 100.
And when you take compound a brings it from 100, to at 20 points, you take compound B individually, and it also brings it from 100 to 8020. Points. The question is what happens when you take both of these together, if it brings it down by 40 points, which means 20, and 20.
That’s called an additive effect, which means Oh, I know ginger will bring it down 100 points, I mean, 20 points, and curcumin will bring it down 20 points. So if I mix them together, I’m gonna get an additive effect. But there’s something even more powerful if you take compound a and compound B, and it’s not in the additive range, which is zero to 40.
But it actually brings it down even lower, like maybe to 60, which means the whole is greater than the sum of the parts. So this is something we call the synergistic effect. So if you go see if you go get a supplement bottle at wherever, and you look at all these compounds, and they say, Oh, this is going to be for this, how do you know and the reality is people don’t know.
But which cytosol, we can calculate that. And we’re going to now walk you through the example we’re going to use it on. So basically, we took a harsh standard, and we applied it to ourselves or a strict standard.
So we’re going to walk you through that on how this was done. So this is the pathway, one of those five for reducing Cox two is something we want to reduce when this is high, you got lot of pain potential. So we want to bring this down.
So what did we do here? So with our combination, again, with the what we did on in silico, is we took this combination of those compounds, and we tested it. So control condition is when you have this is at a high level, right provoca this inflammation is going on your body, when inflammation is going on, you’re going to have at the cell surface close to eight nanomolar as Cox two, if we just give one of the ingredients epogen and brings it down here if we just give His Spirit and it brings it down here, but when we give the combination at the right dosage it comes brings it down even further. Now the issue is where this brings it down.
Is it additive, or is it synergistic? Well, let’s look at it. So the way we did this was, so we added apigenin first and then we added his ferritin. And that’s one endpoint so it brought it down to 1.
93, Cox two then we rotated we gave his spirit in first and apigenin and abroad were done at 1.54. So this between 1.
54 and 1.93 is called the additive rain and people find that interesting. But watch what happens when we gave our specific ratio of apigenin and asparagus it dropped it down to point two eight, which is better than additive.
So additive range would have just been between these two, but were way better. So when it comes to Cox to do This formulation, according to our analysis has a very powerful effect. It brings it down nearly What’s that like? 700%, right, Brubaker seven times better than here.
So this is what we call the synergistic manner. apigenin has spread and lower Cox two in a synergistic manner not additive. Now let’s look at the next one, PG E two, which is the variable that is involved in the actual discomfort and other kinds of things.
Again, we give when you have it at this level of PG to in your body based on clinical work, that’s when you have swelling and pain and inflammation going on epogen and brings it here has spared and around the same when you combine it, it brings it here now again, is this combination, additive or synergistic. You see if you give apigenin first and disparate and again, one by one, it’s 289. A spirit and epogen is 217.
This is the additive range. So our combination is within the additive range. Yes, it’s still good, but it’s not as powerful as a synergistic effect.
But we can protect ourselves but still good. Now we go to TRP V one, which is involved in the actual creation of pain when you notice here is TRPV. One is oh, we don’t have the other control is way off your chart.
It’s at point o four. It’s like up here. And when you give apigenin it goes down here when you give it a spurt and it comes down here.
But when you give our combination it’s way down here and is that additive or synergistic? Well, the additive range is between point oh two, seven 2.03 to five, and we’re an order of magnitude right out of that range. So again, this is why many of you are likely sharing with us that you’re getting a lot of very, very good feedback on the pain if the pain aspect CGRP which is the next variable of pain.
You notice here point oh five is when you have pain epogen and brings it here has burden but the combination brings it down here and there you go. And again, this is 10 to the power of minus 10. It’s four orders of magnitude bigger.
Yeah, this is quite profound. We’re talking about 10,000 times better than each one taken individually, again, in a synergistic manner lowers that pain. And finally, for reactive oxygen, you see the same thing here.
It’s date of stress control is here, epogen is stays at the level has spared and brings it down here, but the combination here and we find this is also outside of the additive range. So it’s synergistic. So there we go.
So let’s see if there’s any questions your projector. So bottom line is that we have a very powerful way of not only developing supplements, again, V 25, but also looking at other supplements do they work or not? And we’re very excited about this because for the public, this means there’s now a way that you can start knowing if something works or not. Now a lot of the supplement guys are probably going to hate us for this.
But those people who want to create great supplements will love us and if they care about the public Oh provoca we have an interesting question from Terry Lima Rosen, she says Should I take should only be taken when you have pain or also supplement or preventative? Well, if you want to think about it this way, we bring up the so your body is constantly at any point producing Cox two PG two, it’s producing all these chemicals, the issue Terry’s it’s at what level so we have typically found that when people are undergoing considerable pain, again, you should consult with your doctor. It says you know, take six of them, right a heavy dose, but you could take it and we have a number of people who have chronic pain or experience they take about what two a day right? provoker because it prevents these things. So you can use it as at the point like Jeremy, I think in that video said when he had it, he took it and then he saw it diminished.
And then he takes it regularly. So you can do it. It’s I mean these what’s really nice about these ingredients is they’re basically coming from food, they’re concentrated food, they’re the active compounds in food.
So there’s recent studies that have also shown that apigenin, which is bioflavonoids has also shown has some benefits on aging as well. And there’ll be there are a lot of history as smart histories were studies that looked at effective apigenin also the cancer biomarkers as well. And that probably has some bearing on its anti energy activities in anything that has inflammation involved in so apigenin and has played in both of them are powerful anti inflammatories, they should be helpful.
appartenant actually crosses the blood brain barrier. And Alzheimer’s is one of the things that people have started looking at. So anyway, I think the key thing we want to let everyone know is that the movement for truth, freedom and health is always trying to take a systems approach we recommend all of you go to truth freedom health.
com It’s a way and contribute all this research we make available to the public and then there’s a lot of you could get real in the world could get really painful looking at all the political nonsense that goes on. So we have two solutions for that. One is go to to truth, freedom and health.
com. And understand take the science of system so you can really understand how the world is operating. And if you can’t you want to you also have other physical pain.
Well, we also have a solution near Columbia 25 that we are building taking a systems approach. So anyway, thank you, everyone. That’s our talk for today our science talk.
And if you many of you if you guys know people make supplements, doctors let them know. So in summary, what we want to let everyone know is you can look at Promarker Do you want to summarize here? Sure. So after those four indications that we looked at that that contribute towards joint pain and inflammation, we have a waiver invite five biomarkers and then we looked at how combination of that virgin Anna has been found and every 25 years affecting those five biomarkers.
So our study found that using the new newly discovered were finding the synergy or the quantification of synergy Sora. Those biomarkers were synergistically lowered and one of those biomarkers PT two was lowered in an additive manner. Even though those biomarkers have been reduced.
We’re able to quantify in what manner these biomarkers have been reduced by a combination animate me 25. And most of these biomarkers are lowered in a synergistic manner. So that’s why we have this multiplicative effect of this particular combination on four or five biomarkers subpoenaed permission so that was a pretty significant finding.
All right, everyone, thank you very much, everyone. Be the light be Well, thank you.
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