Dr. V.A. Shiva Ayyadurai
Inventor of Email and Systems Scientist
Computational Systems Biology: The Future of Precision Medicine at National Center for Advancing Translational Sciences
Dr. V.A. Shiva Ayyadurai delivered a distinguished lecture at National Center for Advancing Translational Sciences (NCATS) on Thursday, January 21, 2016 from 1.00 pm to 3.00 pm. The topic of Dr. Shiva’s lecture was Computational Systems Biology: The Future of Precision Medicine. The main lecture was from 1 pm to 2 pm, following which Dr. Ayyadurai interacted with audience till 3 pm.
Precision medicine aims to move beyond the “one-size-fits-all-approach” by understanding complex biological mechanisms to predict which treatments will be most effective for the right person. This lecture focused on recent developments in computational systems biology that will enable the realization of precision medicine. Recent successes, through multiple case studies, in the use of CytoSolve, a computational systems biology collaboratory, developed at M.I.T., which provides a scalable approach to mechanistic modeling of complex molecular mechanisms was shared. Previous approaches, solely based on statistical techniques, have been unscalable in eliciting the complexity of biological mechanisms. Examples include: accelerating drug discovery, drug repurposing, validation of complementary and alternative medicine (CAM) therapies, and identification of efficacious multi-combination therapeutics. Various institutions at the NIH may likely benefit from this lecture that will provide an introduction to a disruptive platform that will likely revolutionize development of therapeutics in the 21st century.